Discovering the Genome is a web-based curriculum for science classes. The curriculum consists of modules that introduce genomics to students.  The modules include videos, activities, discussion questions, and other tools so students can  explore and discover the genome.

Course Module Features

  • Modules are listed on the left in order of foundational topics to more advanced topics.
  • Modules are designed to be self-contained and can be used as a whole or in sections that enhance your existing curriculum.
  • Module descriptions and educator tips are in the For Teachers section of the website.
  • Modules can be used in any order that is appropriate for your students.

Genomics is an exciting, quickly advancing technical field. It affects healthcare, food production, natural resources management, and environmental conservation. It stimulates bioengineering and synthetic biology solutions. It answers questions about biology and life that haven’t answered before. It poses many more new questions. We invite you and your students to discover the genome…

J. Hogenesch Lab

RNA Sequencing Is a Powerful Tool

RNA sequencing (RNA-seq) is a powerful technique that allows us to see the structure and quantity of RNA molecules in cells and tissues. To assess biases in RNA-seq data, we generated RNA using an in vitro transcription reaction, and prepared this RNA for sequencing with several of the most commonly used methods. We found that our ability to detect particular regions of RNA transcripts was significantly affected by the method we used to prepare RNA for sequencing. It is important that we understand these biases; otherwise, the experimental techniques we use could mask the underlying biology we are ultimately trying to study. For a more detailed description of this work and other results, please click here.